郭 勇

一、基本情况

郭勇，化员工物学博士；特聘教授，博士生导师。主要从事天然活性成分的发现、结构优化、生物活性及构效关系的研究。先后承担国家自然基金—面上、青年基金项目、河南省优秀青年科学基金和湖南省自然科学基金部门联合基金等课题。在J. Med. Chem., Chin. Chem. Lett., Eur. J. Med. Chem., J. Agri. Food Chem., Ind. Crop Prod., Bioorg. Chem.等SCI期刊发表论文50多篇，其中封面论文3篇，ESI高被引3篇。

Email: guoyong_122@163.com

二、研究领域

1. 天然药物先导发现及机制研究。

2.含氮杂环活性功能小分子合成及生物活性评价。

三、社会兼职

Tradit Med Res、Current Topics in Medicinal Chemistry、molecules、Acta Materia Medica等杂志青年或客座编委

四、教学工作

目前承担课程：本科生天然药物化学、研究生高等药物化学与药学前沿进展等课程。

五、承担课题

1. 国家自然科学基金面上项目，项目号：32272575，2023.1-2026.12

2. 湖南省自然科学基金部门联合基金，项目号：2024JJ8141，2024.1-2026.12

六、代表性文章

1. Yang, R., Cui, Li, Xu, S., Zhong, Y., Xu, T., Liu, J., Lan, Z., Qin, S., Guo, Y*. Membrane-Targeting Amphiphilic Honokiol Derivatives Containing an Oxazole Moiety as Potential Antibacterials against Methicillin-Resistant Staphylococcus aureus, Journal of Medicinal Chemistry, 2024, https://doi.org/10.1021/acs.jmedchem.4c01860.

2. Xu, T., Yan, X., Kang, A., Yang, L., Li, X., Tian, Y., Yang, R. *, Qin, S. *, Guo, Y*. Development of membrane-targeting fluorescent 2-phenyl-1H-phenanthro [9, 10-d] imidazole-antimicrobial peptide mimic conjugates against methicillin-resistant Staphylococcus aureus. Journal of Medicinal Chemistry, 2024, 67(11), 9302-9317.

3. Yao, H., Cui, L., Liu, H., Li, X., Shen, L., Yang, R.*, Qin, S*., Guo, Y*. Quinoline-based anti-MRSA agents: Current development, structure-activity relationships, and mechanisms. Chinese Chemical Letters, 2024, 108511.

4. Yang, R., Cheng, W., Huang, M., Xu, T., Zhang, M., Liu, J., Qin, S., Guo, Y*. Novel membrane-targeting isoxanthohumol-amine conjugates for combating methicillin-resistant Staphylococcus aureus (MRSA) infections. European Journal of Medicinal Chemistry, 2024, 116274.

5. Cheng, W., Xu, T., Cui, L., Xue, Z., Liu, J., Yang, R.*, Qin, S*., Guo, Y*. Discovery of Amphiphilic Xanthohumol Derivatives as Membrane-Targeting Antimicrobials against Methicillin-Resistant Staphylococcus aureus. Journal of Medicinal Chemistry, 2023, 66(1), 962-975.

6. Yang, R., Hou, E., Cheng, W., Yan, X., Zhang, T., Li, S., Yao, H.*, Liu, J.*, Guo, Y*. Membrane-targeting neolignan-antimicrobial peptide mimic conjugates to combat methicillin-resistant Staphylococcus aureus (MRSA) infections. Journal of Medicinal Chemistry, 2022, 65(24), 16879-16892.

7. Guo, Y*., Hou, E., Wen, T., Yan, X., Han, M., Bai, L. P., Liu, J.*, Qin, S*. Development of membrane-active honokiol/magnolol amphiphiles as potent antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA). Journal of Medicinal Chemistry, 2021, 64(17), 12903-12916.