Private Information:
Country: China Gender: Male
Date of birth: 1975/12/06
Units of work: Department of Pharmacy, University of South China, Hengyang, Hunan Province
Zip code: 421001
Address: 28# Changsheng West Road, Hengyang city, Hunan province, Republic of China
Mobile Phone: +86-18390959848
Home Tel: +86-0734-8281782
Fax: +86-0734-8282914
Email: caoxuancx@gmail.com
09/2019-12/2020 Visiting Scholar in University of California Riverside, College of chemistry and chemical engineering, USA.
10/2015-6/2018 PhD of Analytical Chemistry, Doctoral student, Department of Chemistry, Tsinghua University, Beijing, China
06/2012-10/2015 PhD of Analytical Chemistry, Doctoral student, College of chemistry and chemical engineering, State Key Laboratory of Chemo/Biosensing and Chemo-metrics, Hunan University, Changsha, China
09/2000-06/2003 Master of Analytical Chemistry, College of chemistry and chemical engineering, State Key Laboratory of Chemo/Biosensing and Chemo-metrics, Hunan University, Changsha
6/1995 Bachelor of Chemistry, College of Chemistry, Hunan university of Humanities, Science and Technology.
9/2003-Present Department of Pharmacy, University of South China, Hengyang, Hunan Province, China
(1) Xiaoyu Peng, Yang Li, Junfeng Qu, Lizhi Jiang, Kaiyue Wu, Dan Liu, Yuping Chen, Junmei Peng, Yu Guo, Xuan Cao*. High affinity and low PARP-trapping benzimidazole derivatives as a potential warhead for PARP1 degraders. European Journal of Medicinal Chemistry. 2024, 271(5):116405. DOI:10.1016/j.ejmech.2024.116405.
(2)Yang Li, Junfeng Qu, Lizhi Jiang, Xiaoyu Peng, Kaiyue Wu, Miaojia Chen, Yuanyuan Peng, Xuan Cao*. Application and challenges of nitrogen heterocycles in PROTAC linker. European Journal of Medicinal Chemistry. 2024, 273(5):116520. DOI:10.1016/j.ejmech.2024.116520.
(3)Yang Li, Lizhi Jiang, Junfeng Qu, Xiaoyu Peng, Kaiyue Wu, Miaojia Chen, Yuanyuan Peng, Xuan Cao*. Research Progress and Prospect of Nitrogen-containing Heterocycle in Anti-gastric Cancer Drugs: A Review. Current Medicinal Chemistry. 2024, 24(4). DOI:10.2174/0109298673296147240405113328
(4) Kaiyue Wu, Xiaoyu Peng, Yang Li, Miaojia Chen, Yunfan Liu, Dan Liu, Lizhi Jiang, Yan He, Junmei Peng*, Xuan Cao*. Design, synthesis, and evaluation of 1H-benzo[d]imidazole-4-carboxamide PARP-1 inhibitors using different saturated nitrogen-contained heterocycle as linker group. Chemical Biology & Drug Design. 2023, 101(6): 1335-1347. DOI: 10.1111/cbdd.14216
(5) Kaiyue Wu, Miaojia Chen, Xiaoyu Peng, Yang Li, Guotao Tang, Junmei Peng, Xuan Cao*. Recent progress of research on the benzimidazole PARP-1 inhibitors, Mini-Reviews in Medicinal Chemistry. 2022, 22(19): 2438-2462. DOI: 10.2174/1389557522666220321150700.
(6) Kaiyue Wu, Xiaoyu Peng, Miaojia Chen, Yang Li, Guotao Tang, Junmei Peng, Yuanyuan Peng, Xuan Cao*. Recent progress of research on anti-tumor agents using benzimidazole as the structure unit, Chemical Biology & Drug Design. 2022, 99(5): 736-757. DOI: 10.1111/cbdd.14022.
(7) Miaojia Chen, Honglin Huang, Kaiyue Wu, Guotao Tang, Junmei Peng, Xuan Cao*. Synthesis and evaluation of 2-(4-[4-acetylpiperazine-1-carbonyl] phenyl)-1H-benzo[d]imidazole-4-carboxamide derivatives as potential PARP-1 inhibitors and preliminary study on structure-activity relationship, Drug Development Research, 2021, 83(1): 55-63. DOI:10.1002/ddr.21843
(8) Jinmei Qiu, Changfeng Qin, Shengen Wu, Tongying Ji, Guotao Tang, Xiaoyong Lei, Xuan Cao*, Zhizhong Xie*. A novel salvianolic acid A analog with resveratrol structure and its antioxidant activities in vitro and in vivo. Drug Development Research, 2020, 82(6): 108-114. DOI:10.1002 /ddr.21734
(9) Jingjing Feng#, Xuan Cao# (co-author), Qi Pan, Yan He.* Direct observation of Single Plasmonic Metal Nanoparticle Reaction in Microcolumn with Chromatic-Aberration-Free Laser Light-Sheet Scattering Imaging. Electrophoresis, 2019, 40(13):1747-1753 DOI: 10.1002/elps.201900071
(10) Xuan Cao#, Gang Lei#, JingJing Feng, Qi Pan, Yan He.* A Novel Color Modulation Analysis Strategy through Tunable Multiband Laser for Nanoparticle Identification and Evaluation, Analytical Chemistry, 2018, 90(4):2501-2507. DOI:10.1021/acs.analchem. 7b03636.
(11) Xuan Cao, Jingjing Feng, Qi Pan, Bin Xiong, Yan He,* and Edward S. Yeung. Direct Imaging of Single Plasmonic Metal Nanoparticles in Capillary with Laser Light-Sheet Scattering Imaging. Analytical Chemistry, 2017. 89(2):2692-2697. DOI:10.1021 /acs.analchem.6b03844.
(12) Xiaodong Cheng, Xuan Cao, Bin Xiong, Yan He,* and Edward S. Yeung. Background-free three-dimensional selective imaging of anisotropic plasmonic nanoparticles. Nano Research, 2017. 10(4):1423-1433. DOI: 10.1007/s12274-017-1524-4
(13)Lan Peng, Xuan Cao, Bin Xiong,* Yan He* and Edward S. Yeung. A novel scattering switch-on detection technique for target-induced plasmon-coupling based sensing by single-particle optical anisotropy imaging. Chemical Communications, 2016, 52(2):7616-7619. DOI: 10.1039/ c6cc02536f
Research Interest
Pharmaceutical Chemistry; medicinal Chemistry; Computational Chemistry
1) Design and total synthesis of small molecules such as PARP1 inhibitor.
2) Design and total synthesis of Natural anti-tumor agents. (In progressing)
3) Data analysis or QSAR study of medicinal chemistry.
4) Theoretical calculations for the prediction of IC50 of the compounds.
5) Theoretical calculations for the weak force based (non-covalent bond) molecular interactions.